COLISTIN RESISTANCE IN CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE STRAINS
نویسندگان
چکیده
منابع مشابه
Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan.
Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing...
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M. Monaco1,2, T Giani2,3, M Raffone1,4, F Arena3, A Garcia-Fernandez1, S Pollini3, Network EuSCAPE-Italy5, H Grundmann6, A Pantosti ([email protected])1, G M Rossolini3,7,8 1. Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy 2. MM and TG have equally contributed to this work 3. Department of Medical Biotechnologies, University of...
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BACKGROUND Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR mechanisms of CRKP and identified their clonal characteristics. METHODS PCR and sequencing were utilized to identify antibiotic resistance determinants. Integron ...
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OBJECTIVES Antimicrobial therapy for sepsis caused by carbapenem- and colistin-resistant Klebsiella pneumoniae is not well established. We hypothesized that the early use of gentamicin in cases due to susceptible organisms would decrease the crude mortality rate of this infection. METHODS This retrospective cohort study examined 50 cases of sepsis caused by carbapenem-resistant K. pneumoniae ...
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Carbapenem-resistant Klebsiella pneumoniae (CRKP) is resistant to almost all antimicrobial agents, is associated with substantial morbidity and mortality, and poses a serious threat to public health. The ongoing worldwide spread of this pathogen emphasizes the need for immediate intervention. This article reviews the global spread and risk factors for CRKP colonization/infection, and provides a...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2017
ISSN: 2455-3891,0974-2441
DOI: 10.22159/ajpcr.2017.v10i9.18369